Doxylamine, L-Methylfolate, P-5-P & Methylcobalamin

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Therapeutic Indication

Nausea and vomiting of pregnancy (morning sickness)
Supportive therapy in prenatal care
Neural tube defect prevention
Vitamin B6 and B12 supplementation
Adjunct therapy in nutritional deficiencies
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Doxylamine, L-Methylfolate, P-5-P & Methylcobalamin

Tablet

This fixed-dose combination provides comprehensive support in pregnancy and nutritional health. Doxylamine Succinate, an antihistamine, reduces nausea and vomiting. L-Methylfolate Calcium supports folate metabolism and fetal neural development. Pyridoxal-5-Phosphate (active Vitamin B6) alleviates nausea and supports neurotransmitter synthesis. Methylcobalamin (active Vitamin B12) aids in nerve health and red blood cell formation.

Speciality Antiemetic / Prenatal & Nutritional Supplement
Tags Pregnancy | Morning Sickness | Folate | Vitamin B6 | Vitamin B12
Strength
  • Doxylamine Succinate 20 mg
  • L-Methylfolate Calcium 1 mg
  • Pyridoxal-5-Phosphate 10 mg
  • Methylcobalamin 1500 mcg
Packing Size
  • 10 Tablets

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Mechanism

Doxylamine Succinate acts as an H1 receptor antagonist, reducing nausea. L-Methylfolate Calcium provides bioactive folate for DNA synthesis and neural tube development. Pyridoxal-5-Phosphate supports neurotransmitter metabolism and reduces nausea. Methylcobalamin enhances nerve function and hematopoiesis.

Pharmacokinetics

  • Doxylamine: Rapid absorption, hepatic metabolism, half-life ≈ 10 hours
  • L-Methylfolate: Active form of folate, readily bioavailable
  • Pyridoxal-5-Phosphate: Converted from Vitamin B6, long tissue half-life
  • Methylcobalamin: Active Vitamin B12, stored in liver, half-life ≈ 6 days

Side Effects

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Rare: allergic reactions

Contraindication

  • Hypersensitivity to any component
  • Severe hepatic impairment

Interaction

  • Alcohol and CNS depressants — additive sedation with Doxylamine
  • Levodopa — reduced efficacy with Pyridoxine derivatives
  • Antiepileptics — may reduce folate and B12 levels

Warning and Precautions

  • Use under medical supervision during pregnancy
  • Monitor for excessive sedation
  • Ensure adequate folate and B12 supplementation